Psoriasis, a Systemic Disease?
نویسندگان
چکیده
منابع مشابه
Psoriasis, a Systemic Disease?
It has long been recognized the epidemiological association of psoriasis, especially the most severe forms, with several diseases that share a common pathogenic substrate involving TNF-α and different target organs (arthritis and Crohn disease, for example), as well as an increased risk of coronary heart disease and occlusive cardiovascular disease. In the patient with severe psoriasis there is...
متن کامل[Psoriasis, a systemic disease?].
It has long been recognized the epidemiological association of psoriasis, especially the most severe forms, with several diseases that share a common pathogenic substrate involving TNF-alpha and different target organs (arthritis and Crohn's disease, for example), as well as an increased risk of coronary heart disease and occlusive cardiovascular disease. In the patient with severe psoriasis th...
متن کاملPsoriasis: A Disease of Systemic Inflammation with Comorbidities
The majority of the current data about psoriasis is about immune system elements and role of inflammation in the pathogenesis. The development of psoriasis is associated with genetic predisposition which has a basis of T cell activation secondary to dermal inflammation with abnormal keratinocyte proliferation. Tumor necrosis factor alpha (TNF-α), interferon gama (IFN-γ), and interleukin (IL)-8 ...
متن کاملPsoriasis as the marker of underlying systemic disease.
Psoriasis is associated with comorbidities that include metabolic syndrome and increased cardiovascular risk. These conditions share etiologic features and health consequences that directly correlate with the severity of psoriatic disease. This disease, in both its skin and joint manifestations, may represent a relevant healthcare issue as an indicator of a broader, underlying disorder of syste...
متن کاملSystemic Treatment of Pediatric Psoriasis: A Review
Psoriasis is a chronic, immune-mediated, inflammatory skin disease, affecting 1-3% of the white population. Although the existence of two psoriasis incidence peaks has been suggested (one in adolescence before 20 years of age and another in adulthood), its onset may occur at any age, including childhood and adolescence, in which the incidence is now estimated at 40.8 per 100,000. As for adult p...
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ژورنال
عنوان ژورنال: Turkish Journal of Dermatology / Türk Dermatoloji Dergisi
سال: 2012
ISSN: 1307-7635,1308-5255
DOI: 10.5152/tdd.2012.27